Includes bibliographical references (pages 299-304) and index.

Introduction: An epidemic foretold -- Act I: Dealing. The undertaker ; Junk science ; Pilliamson ; The sales pitch ; What they knew ; Investigation ; Vital sign -- Act II: Hooked. A loaded gun in the suicide ward ; Paying to play ; Pursuit ; The silence ; Pushback ; Sounding the alarm ; Kermit ; A free pass ; The end of days -- Act III: Withdrawal. The public health ; Russian roulette ; Dodging torpedoes ; The national nightmare ; Guilt.

"A comprehensive portrait of a uniquely American epidemic--devastating in its findings and damning in its conclusions. The opioid epidemic has been described as 'one of the greatest mistakes of modern medicine.' But calling it a mistake is a generous rewriting of the history of greed, corruption, and indifference that pushed the US into consuming more than 80 percent of the world's opioid painkillers. Journeying through lives and communities wrecked by the epidemic, Chris McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs, but the corrupting of medicine and public institutions that let the opioid makers get away with it. The starting point for McGreal's deeply reported investigation is the miners promised that opioid painkillers would restore their wrecked bodies, but who became targets of 'drug dealers in white coats.' A few heroic physicians warned of impending disaster. But American Overdose exposes the powerful forces they were up against, including the pharmaceutical industry's coopting of the Food and Drug Administration and Congress in the drive to push painkillers--resulting in the resurgence of heroin cartels in the American heartland. McGreal tells the story, in terms both broad and intimate, of people hit by a catastrophe they never saw coming. Years in the making, its ruinous consequences will stretch years into the future."--Dust jacket.

Journeying through lives and communities wrecked by the opioid epidemic, McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs, but the corrupting of medicine and public institutions that let the opioid makers get away with it. A few physicians warned of impending disaster, but the forces they were up against-- including the pharmaceutical industry's coopting of the Food and Drug Administration and Congress in the drive to push painkillers-- resulted in the resurgence of heroin cartels in the American heartland. McGreal shows how its ruinous consequences will stretch years into the future. -- adapted from jacket.

Text in English.